TY  - GEN
T1  - New allele of C. elegans gene pign-1, named as xyz11
AU  - Narimatsu, Tetsuya
AU  - Ihara, Shinji
DO  - 10.17912/micropub.biology.000088
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000088/
AB  - The C. elegans ortholog of PIGN (phosphatidylinositol glycan anchor biosynthesis, class N) is encoded by pign-1. PIGN-1/PIGN is known to be an enzyme that catalyzes the transfer of phosphoethanolamine (EtNP) to the first mannose residue at precursors of glycosylphosphatidylinositol (GPI) anchor (canonical function) and the enzymatic activity is essential for the viability of C. elegans (Gaynor et al., 1999; Hong et al., 1999; Ihara et al., 2017). We recently identified a non-canonical function of PIGN-1 to prevent protein aggregation within the endoplasmic reticulum (ER) independently of its function in GPI biosynthesis (Ihara et al., 2017).
PY  - 2019
JO  - microPublication Biology
ER  -