TY  - GEN
T1  - The autophagy gene product BEC-1 supports normal aging and neurodevelopment in Caenorhabditis elegans I
AU  - Ashley, Nicholas
AU  - Holgado, Andrea M
DO  - 10.17912/micropub.biology.000099
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000099/
AB  - Macroautophagy (hereon referred as Autophagy) is a cellular housekeeping mechanism that uses a double membrane to target and engulf cell products forthe formation of autophagosomes. These double membrane organelles then fuse to lysosomes where cell products are degraded and recycled (Nakamura and Yoshimori, 2018). Reports show that autophagy plays an important role in pathogen defense, development, starvation adaptations, and aging (Mizushima et al., 2008). Identifying molecular mechanisms responsible for autophagy in mammalian cells has been possible as a result of studying model systems, such as Saccharomyces cerevisiae. Autophagy related genes (Atg) are evolutionarily conserved; therefore, research of autophagy in simpler organisms have informed the roles of Atg in mammalian cells (Ruck et al., 2011; Mercer et al., 2018; Tyler and Johnson, 2018). Analysis of autophagy mutants in C. elegansrevealed that bec-1/Atg6/Beclin 1 is essential for dauer development, a quiescent state that survives harsh conditions such as lack of nutrients, high nematode density, and high temperatures by inducing autophagy (Meléndez et al., 2003; Meléndez and Levine 2009).
PY  - 2019
JO  - microPublication Biology
ER  -