TY  - GEN
T1  - UNC-42 function is required for the ectopic expression of ASH markers in mls-2 mutant animals
AU  - Wood, Jordan F
AU  - Ferkey, Denise M
DO  - 10.17912/micropub.biology.000116
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000116/
AB  - The HMX/NKS homeodomain transcription factor MLS-2 is required to initiate the expression of the AWC terminal selector ceh-36, and as such the AWCs of mls-2 loss-of-function mutant animals fail to express downstream AWC-specific terminal differentiation genes (Kim et al., 2010).  Interestingly, loss of mls-2 function was also shown to result in ectopic expression of ASH markers (sra-6p::gfp and osm-10p::gfp) in at least one neuron in a large percentage of mls-2 mutant animals (Kim et al., 2010).  The cells that ectopically express the ASH markers are adjacent to the native ASHs and, like native ASH neurons, dye-fill with lipophilic dyes such as DiD (Perkins et al., 1986; Kim et al., 2010).
PY  - 2019
JO  - microPublication Biology
ER  -