TY  - GEN
T1  - Role of the p38 MAP kinase pathway in C. elegans surface antigen switching
AU  - Politz, Samuel M
DO  - 10.17912/micropub.biology.000130
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000130/
AB  - In Van Sciver et al, 2019 and Honzel et al, 2019, we showed that the gene previously described as srf-6 is actually nsy-1, which encodes NSY-1, the MAPKKK in the C. elegans p38 pathway.  In earlier work, we had shown that srf-6 mutations affect timing of expression of a surface epitope (Hemmer et al., 1991).  Wild-type worms express the epitope only at the L1 stage, but srf-6 mutants express it additionally at stages L2-L4 (called CLD for Constitutive Larval Display).  In addition, we reported that wild-type worms can display the L1-specific epitope on stages L2-L4 when grown on a modified medium containing the concentrated extract of liquid nematode culture medium (called ILD for Inducible Larval Display, Grenache et al., 1996).  Thus the expression of the L1-specific epitope appears to be controlled by an inducible switch that is under control of the srf-6 gene, which, as we now know, is a component of the p38 MAP kinase pathway in C. elegans. The srf-6 mutant phenotype, according to this model, corresponds to a switch that is constitutively “on”. srf-6(yj13) has a CLD phenotype similar to that of a large nsy-1 deletion, suggesting that SRF-6 may function to inhibit expression of the L1-specific epitope after the L1 stage. 
PY  - 2019
JO  - microPublication Biology
ER  -