TY  - GEN
T1  - Caenorhabditis Intervention Testing Program: the tyrosine kinase inhibitor imatinib mesylate does not extend lifespan in nematodes
AU  - Coleman-Hulbert, Anna L
AU  - Johnson, Erik
AU  - Sedore, Christine A
AU  - Banse, Stephen A
AU  - Guo, Max
AU  - Driscoll, Monica
AU  - Lithgow, Gordon J
AU  - Phillips, Patrick C
DO  - 10.17912/micropub.biology.000131
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000131/
AB  - The Caenorhabditis Intervention Testing Program (CITP) is a National Institutes of Aging (NIA)-funded multi-institutional research consortium that investigates chemical interventions for their potential to extend lifespan and healthspan across a genetically diverse panel of Caenorhabditis nematodes (Lucanic et al., 2017a). To date, the CITP has tested more than 20 compounds, including many of those previously surveyed in mice by the NIA-funded Interventions Testing Program (ITP) (Miller et al., 2007; Nadon et al., 2008). With compounds tested across multiple strains, species, labs, and concentrations, the CITP produces a large body of work before a compound traverses the full testing workflow. The intensive effort required poses an important challenge for the CITP as to how to systematically identify and prioritize compounds to test. Indeed, the selection of chemical interventions that might hold the greatest potential for efficacy is a challenge to the aging field in general.
PY  - 2019
JO  - microPublication Biology
ER  -