TY  - GEN
T1  - aptf-1 mutants are primarily defective in head movement quiescence during C. elegans sleep
AU  - Robinson, Bryan
AU  - Goetting, Desiree L
AU  - Cisneros Desir, Janine
AU  - Van Buskirk, Cheryl
DO  - 10.17912/micropub.biology.000148
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000148/
AB  - Behavioral quiescence during sleep states can be measured by a variety of methods, each with advantages and limitations (Nagy et al., 2014). Centroid tracking gives information about locomotion (place-to-place movement) but may not register small head movements or other changes in body posture that do not change centroid position. Frame subtraction methods, based on analysis of pixel intensity changes between successive frames, register any movement as non-quiescent, but do not categorize the nature of movement. Counting body bends is a close proxy to locomotion (Karbowski et al., 2006) but can be time-consuming if done manually. Last, while nose tip movement has been observed to approximate body movement during C. elegans sleep (Bringmann, 2011), this approximation may not apply to mutants defective in only one of these behaviors. Here we provide an example of such a case.
PY  - 2019
JO  - microPublication Biology
ER  -