TY  - GEN
T1  - The role of lrp-2 in C. elegans vulval cell lineage polarity
AU  - Minor, Paul J
AU  - Sternberg, Paul W
DO  - 10.17912/micropub.biology.000155
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000155/
AB  - We investigated the role of the low-density lipoprotein receptor lrp-2 in C. elegans vulval cell lineage polarity. We find that despite the high conservation of the Wnt signaling component, LRP5/6, in higher order organisms it appears to have evolved after the split of Nematoda due to its absence in all nematode genomes examined. C. elegans contains multiple low-density lipoprotein receptors within its genome, two of which are lrp-1 and lrp-2. Due to the position in the genome and high sequence similarity we believe that lrp-2 is the product of a recent duplication of lrp-1 within the Caenorhabditis lineage (Minor and Sternberg, 2019d).
PY  - 2019
JO  - microPublication Biology
ER  -