TY  - GEN
T1  - Interspecific comparison of sensitivity to paralytic compounds
AU  - Le, Vivian Vy
AU  - Sanchez, Bryan
AU  - Hong, Ray L
DO  - 10.17912/micropub.biology.000185
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000185/
AB  - Identifying the genetic loci conferring resistance to anthelmintic compounds is of paramount importance in assessing and monitoring their effectiveness in the long term. Although Caenorhabditis elegans has been a useful reference point for research in parasitic nematodes, a comparative approach using additional genetically tractable nematodes could uncover other unknown factors that contribute to drug sensitivity. To better understand how diverse non-parasitic nematodes respond to known paralytic compounds with anthelmintic activity, we compared for the first time the response of an entomophilic nematode Pristionchus pacificus and C. elegans to betaine, levamisole, and ivermectin. In addition to paralytic compounds that require physical contact, we also examined the responses toward the volatile anesthetic halothane.
PY  - 2019
JO  - microPublication Biology
ER  -