TY  - GEN
T1  - C. elegans rab-18 mutants display reduced lipid content under fed and fasted conditions
AU  - Ratemi, Zakaria
AU  - Kiss, Robert S
AU  - Rocheleau, Christian E
DO  - 10.17912/micropub.biology.000188
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000188/
AB  - The excessive storage of neutral lipids in lipid droplets (LDs) is a consequence of excess dietary nutrient uptake and the primary cause of major metabolic disorders, including obesity, diabetes, and atherosclerosis (Eckel et al., 2005).  Several studies investigating proteins associated with the monolayer surface of LDs have identified the Rab18 GTPase as a component with a role in the regulation of fat storage and lipid mobilization (Martin et al., 2005; Ozeki et al., 2005). Rab18, a small GTPase protein localized on the surface of LDs, plays a key role in several LD-related processes, including lipogenesis, lipolysis, and lipophagy (Pulido et al., 2011; Schulze et al., 2017).  Although Rab18 has been previously associated with multiple roles in lipid metabolism, including mediating the apposition of LDs to the ER, its fundamental function remains disputed (Ozeki et al., 2005).  To better understand the function of Rab18 in fat control at the organismal level, we proceeded to investigate the effect of rab-18 knockout on overall lipid abundance in C. elegans.
PY  - 2019
JO  - microPublication Biology
ER  -