TY  - GEN
T1  - TOM1 confers resistance to the aminoglycoside hygromycin B in Saccharomyces cerevisiae
AU  - Niekamp, Julia M
AU  - Evans, Melissa D
AU  - Scott, Abigail R
AU  - Smaldino, Philip J
AU  - Rubenstein, Eric M
DO  - 10.17912/micropub.biology.000193
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000193/
AB  - The ubiquitin ligase Tom1p contributes to regulated protein degradation, protein quantity control, and protein quality control in Saccharomyces cerevisiae. While GFP-tagged Tom1p is found in both the cytosol and nucleus, the majority of the protein is nuclear (Defenouillere et al. 2017). Among other substrates, Tom1p promotes the turnover of the DNA replication factor Cdc6p (Kim et al. 2012) and the ubiquitin ligase Dia2p (Kim and Koepp 2012) in a cell cycle-dependent manner. The enzyme also mediates the destruction of supra-stoichiometric histone molecules (Singh et al. 2009) and ribosomal proteins (Sung et al. 2016). Further, Tom1p promotes the solubility of multiple aggregation-prone proteins (Theodoraki et al. 2012; Defenouillere et al. 2017). Knockout or knockdown of the mammalian homolog Huwe1 stabilizes excess ribosomal proteins (Sung et al. 2016), suggesting conservation of enzyme function.
PY  - 2019
JO  - microPublication Biology
ER  -