TY  - GEN
T1  - Caenorhabditis Intervention Testing Program: the creatine analog β-guanidinopropionic acid does not extend lifespan in nematodes
AU  - Coleman-Hulbert, Anna L
AU  - Johnson, Erik
AU  - Sedore, Christine A
AU  - Banse, Stephen A
AU  - Guo, Max
AU  - Driscoll, Monica
AU  - Lithgow, Gordon J
AU  - Phillips, Patrick C
DO  - 10.17912/micropub.biology.000207
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000207/
AB  - The Caenorhabditis Intervention Testing Program (CITP) is a multi-institutional, National Institutes of Aging (NIA)-funded consortium charged with identifying chemical compounds that robustly extend lifespan in a genetically diverse panel of Caenorhabditis strains. Compounds are prioritized for screening if they are highly ranked via computational prediction for lifespan or healthspan effects (Coleman-Hulbert et al. 2019), if they are predicted to engage known lifespan regulating pathways, or if they have previously been reported as extending lifespan or healthspan in model systems (Lucanic et al. 2017). β-guanidinopropionic acid (β-GPA) is a creatine analog (Shields and Whitehair 1973), commonly used as a dietary supplement, and has been shown to extend lifespan in Drosophila under stress via 5′ AMP-activated protein kinase (AMPK) activity (Yang et al. 2015). The AMPK pathway is conserved in nematodes and humans (Apfeld et al. 2004) and is involved in multiple pathways affecting stress response and metabolism (Wang et al. 2012).
PY  - 2020
JO  - microPublication Biology
ER  -