TY  - GEN
T1  - tmem-258 is dispensable for both nuclear anchorage and migration in C. elegans
AU  - Gregory, Ellen Faith
AU  - Starr, Daniel Aaron
DO  - 10.17912/micropub.biology.000208
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000208/
AB  - Human TMEM258 is involved in stress pathways and has been implicated in inflammatory intestinal disorders (Graham et al., 2016). The Drosophila ortholog Kuduk consists of a transmembrane and an intramembrane domain and localizes to the outer nuclear membrane, where it regulates myonuclear positioning and morphology (Ding et al., 2017). Kuduk is the first characterized cytoplasmic regulator of the LINC (linker of nucleoskeleton and cytoskeleton) complex. LINC complexes are conserved throughout eukaryotes and consist of SUN (Sad-1 and UNC-84) proteins, which localize to the inner nuclear membrane and bind to lamin, and KASH proteins (Klarsicht, ANC-1, Syne homology) that span the outer nuclear membrane and interact with cytoskeletal elements. KASH and SUN bind in the perinuclear space to bridge the nucleus and cytoskeleton and transfer force across the nuclear envelope (Starr, 2009). Drosophila Kuduk has been shown to help anchor the nucleus in place via the LINC complex, but the molecular mechanisms it uses to carry out nuclear migration remain unknown.
PY  - 2020
JO  - microPublication Biology
ER  -