TY  - GEN
T1  - Temperature-sensitive mosquito TRP channel rescues touch deficits caused by knock-out of a DEG/ENaC channel in C. elegans glia
AU  - Wang, Ying
AU  - Bianchi, Laura
DO  - 10.17912/micropub.biology.000209
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000209/
AB  - Recent studies have shown that accessory cells of mammalian touch receptors, such as the Merkel receptors, play an essential role in transducing touch (Pawson et al., 2009, Maricich et al., 2009, Maksimovic et al., 2014, Woo et al., 2014, Ikeda et al., 2014, Woo et al., 2015). Similarly, in C. elegans, we found that OLQ and IL glial socket cells are needed for responses to nose touch. More specifically, we reported that these glial cells express DEG/ENaC Na+ channel DELM-1 and DELM-2, which are needed specifically in glia for OLQ neuronal responses to touch and nose-touch avoidance behavior. We also showed that nose touch responses are restored by overexpression of the worm inward rectifier K+ channel IRK-2 in socket glia of delm-1 mutants (Han et al., 2013). These published results suggest that glial Na+ and K+ channels are needed for the function of the associated touch receptor neurons.
PY  - 2020
JO  - microPublication Biology
ER  -