TY  - GEN
T1  - Calx, a sodium/calcium exchanger, may affect lifespan in Drosophila melanogaster
AU  - Mok, Jung-Wan
AU  - Chung, Hyunglok
AU  - Choi, Kwang-Wook
DO  - 10.17912/micropub.biology.000220
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000220/
AB  - Calcium homeostasis is essential for normal body function. Calx is a Drosophila homolog of the mammalian sodium/calcium exchanger (NCX) involved in the regulation of intracellular calcium (Ca2+) level (Schwarz and Benzer 1997). A major function of Calx is to export excess Ca2+ to the outside of the cell when intracellular Ca2+ level is elevated (Hryshko et al. 1996). Genetic studies in Drosophila have shown that Calx mutants can develop to adult flies, even though Calx is expressed throughout the developmental stages (Wang et al. 2005). However, Ca2+ efflux mediated by Calx is crucial for maintaining the cellular Ca2+ homeostasis in light-activated sensory neurons (Wu et al. 2011). In addition to its role for phototransduction, Calx is also required for preventing light-induced retinal degeneration caused by Ca2+ overload (Wang et al. 2005).
PY  - 2020
JO  - microPublication Biology
ER  -