TY  - GEN
T1  - Loss of proteasome subunit RPN-12 causes an increased mean lifespan at a higher temperature in C. elegans
AU  - Fernando, Lourds
AU  - Nguyen, Victoria
AU  - Hansen, Tyler
AU  - Golden, Andy
AU  - Allen, Anna
DO  - 10.17912/micropub.biology.000234
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000234/
AB  - The 26S proteasome is one of the major proteolytic machineries in cells and is composed of nearly 33 different subunits (Budenholzer et al., 2017; Chen et al., 2008; Papaevgeniou and Chondrogianni, 2014). The subunits are arranged as one or two 19S regulatory particle(s) capping a cylindrical catalytic 20S core particle (Budenholzer et al., 2017). Each subunit is highly conserved from yeast to mammals, and proper function of the proteasome is crucial for survival of organisms (Papaevgeniou and Chondrogianni, 2014). Spatiotemporal expression of specific subunits and their roles in regulating the proteasome activity is still not clearly understood.
PY  - 2020
JO  - microPublication Biology
ER  -