TY  - GEN
T1  - Difference in phenotypic severity of presumed null alleles of capg-1
AU  - VanDiepenbos, Sarah
AU  - Csankovszki, Györgyi
DO  - 10.17912/micropub.biology.000245
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000245/
AB  - Dosage compensation is the mechanism by which organisms correct the sex chromosome imbalance between sexes (e.g. females having two X chromosomes compared to one X in males). In C. elegans, dosage compensation is achieved by the downregulation by half of both X chromosomes in hermaphrodites (Albritton & Ercan, 2018). This downregulation is accomplished by the Dosage Compensation Complex (DCC), which is comprised of a condensin IDC subcomplex interacting with other accessory proteins. Condensin IDC has a similar structure to canonical condensins (condensin I and condensin II), which function to compact chromosomes during mitosis and meiosis (Csankovszki et al., 2009). The DPY-27 subunit is unique to condensin IDC, MIX-1 is present in all three condensins, while the proteins CAPG-1, DPY-26, and DPY-28 are found both in condensin I and condensin IDC (Figure 1A).
PY  - 2020
JO  - microPublication Biology
ER  -