TY  - GEN
T1  - Regulation of sleep by KIN-29 is not developmental
AU  - Grubbs, Jeremy J.
AU  - van der Linden, Alexander M.
AU  - Raizen, David M.
DO  - 10.17912/micropub.biology.000247
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000247/
AB  - Sleep is intertwined with metabolic function in vertebrates (Tsuneki et al. 2016; Herrera et al. 2017; Aalling et al. 2018; Wilms et al. 2018) and invertebrates (Kempf et al. 2019; Ki and Lim 2019; Yurgel et al. 2019; Grubbs et al. 2020), but the molecular underpinnings of this connection are not well understood. We recently reported that the salt inducible kinase (SIK) homolog KIN-29 is required in a subset of sensory neurons for the metabolic regulation of sleep in Caenorhabditis elegans (Grubbs et al. 2020). However, since our genetic manipulations made use of mutations that were present throughout the life of the animal, it is possible that the sleep defect of kin-29 mutants reflects a requirement for KIN-29 activity during development rather than during sleep. Indeed, because kin-29 is expressed throughout development as well as adulthood (Maduzia et al. 2005), and kin-29 mutants show altered expression of targets influential in larval development (Van Der Linden et al. 2008), a role for kin-29 during development remained plausible. Distinguishing a developmental early role from a role during the time of sleep is important for constraining models for how KIN-29 regulates sleep.
PY  - 2020
JO  - microPublication Biology
ER  -