TY  - GEN
T1  - Plant hexokinase phylogenetic analysis highlights a possible regulation by the posttranslational modifier SUMO
AU  - Castro, Pedro Humberto
AU  - Freitas, Sara
AU  - Azevedo, Herlander
DO  - 10.17912/micropub.biology.000260
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000260/
AB  - Hexokinases (HXKs) are central enzymes in the carbohydrate metabolism, by controlling the entry point of glucose into glycolysis, while also displaying regulatory roles. In plants, Arabidopsis thaliana HXK1 (AtHXK1, also known as AtGIN2) is involved in hormonal signalling, which likely explains its involvement in plant growth and development (Moore et al., 2003). One interesting feature of AtHXK1 is that, in the presence of exogenous glucose, it localizes in the nucleus to form a complex that inhibits photosynthesis-associated transcripts (Cho et al., 2006). This feature is central to cope with excess sugar by diminishing sugar biosynthesis. With such a central role, it is likely that AtHXK1 has several layers of regulation, and it is therefore logical that AtHXK1 may be targeted by different posttranslational modifications (PTMs). In support, PTMs such as phosphorylation and ubiquitination have been proposed to control HXK activity in human cells (Zhang et al., 2017; Lee et al., 2019). At the plant level however, the knowledge concerning HXK regulation is very scarce.
PY  - 2020
JO  - microPublication Biology
ER  -