TY  - GEN
T1  - A toolkit of tagged glp-1 alleles reveals strong glp-1 expression in the germline, embryo, and spermatheca
AU  - Sorensen, Erika B
AU  - Seidel, Hannah S
AU  - Crittenden, Sarah L
AU  - Ballard, Joseph H
AU  - Kimble, Judith
DO  - 10.17912/micropub.biology.000271
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000271/
AB  - The C. elegans genome encodes two Notch receptors, GLP-1 and LIN-12 (Greenwald and Kovall, 2013). These receptors function in multiple tissues to regulate development, behavior, and reproduction. GLP-1 controls cell fate decisions in the germline (Kimble and Seidel, 2013) and early embryo (Priess, 2005). LIN-12 controls development of the vulva (Greenwald, 2005; Sternberg, 2005). These receptors also act outside the context of development in post-mitotic neurons to regulate chemosensation (Singh et al., 2011), locomotion (Chao et al., 2005), and life-history decisions (Ouellet et al., 2008). Additional processes regulated by Notch signaling include oocyte growth (Nadarajan et al., 2009) and ovulation (McGovern et al., 2018). Understanding the many functions of Notch signaling therefore requires a global picture of Notch receptor expression.
PY  - 2020
JO  - microPublication Biology
ER  -