TY  - GEN
T1  - The muscarinic agonist arecoline suppresses motor circuit hyperactivity in C. elegans
AU  - McCulloch, Katherine A
AU  - Jin, Yishi
DO  - 10.17912/micropub.biology.000272
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000272/
AB  - Balanced excitation and inhibition activities are critical for proper neural circuit function. The C. elegans locomotor circuit is regulated via the coordinated activities of cholinergic excitation and GABAergic inhibition that promote muscle contraction and relaxation, respectively. A gain-of-function mutation in a neuronal acetylcholine receptor subunit gene, acr-2 [acr-2(gf)], causes both increased cholinergic excitation and decreased GABAergic inhibition to body muscles, resulting in overall hyperactivity of the locomotor circuit. acr-2(gf) mutant animals show Uncoordinated(Unc) movement and spontaneous shrinking, or, convulsion (Jospin et al. 2009).
PY  - 2020
JO  - microPublication Biology
ER  -