TY  - GEN
T1  - Novel actions of arecoline in the C. elegans motor circuit
AU  - McCulloch, Katherine A
AU  - Jin, Yishi
DO  - 10.17912/micropub.biology.000275
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000275/
AB  - acr-2 encodes a nicotinic receptor subunit. A gain-of-function mutation in acr-2 results in uncoordinated (Unc) movement and spontaneous shrinking or convulsion (Jospin, 2009). These phenotypes are the result of elevated cholinergic excitation as well as decreased GABAergic inhibition in the locomotor circuit. We have tested the effect of the muscarinic agonist arecoline on acr-2(gf) convulsion and found that this drug suppressed convulsion and locomotion phenotypes (McCulloch and Jin 2020). Here, we investigated underlying mechanisms and pathways involved in arecoline-induced suppression of acr-2(gf).
PY  - 2020
JO  - microPublication Biology
ER  -