TY  - GEN
T1  - The C. elegans TRPV channel proteins OSM-9 and OCR-2 contribute to aversive chemical sensitivity
AU  - Mehle, Emily A.
AU  - Sojka, Savannah E.
AU  - K.C., Medha
AU  - Zel, Rosy M.
AU  - Reese, Sebastian J.
AU  - Ferkey, Denise M.
DO  - 10.17912/micropub.biology.000277
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000277/
AB  - Transient receptor potential (TRP) channels are a family of cation channels that are important for response to diverse external stimuli across eukaryotes (Venkatachalam and Montell 2007; Samanta et al. 2018). In C. elegans, only members of the TRPV family, which includes osm-9, ocr-1, ocr-2, ocr-3 and ocr-4 (Colbert and Bargmann 1995; Colbert et al. 1997; Tobin et al. 2002), have been shown to play a role in chemosensory behavior (Bargmann 2006). OSM-9 and OCR-2 are co-expressed in six pairs of sensory neurons: AWA, ASH, ADL, ADF, PHA and PHB (Colbert et al. 1997; Tobin et al. 2002). In these cells, they are thought to come together to function as a single channel complex to mediate sensory transduction since their localization to the cilia is mutually dependent upon each other (Tobin et al. 2002).
PY  - 2020
JO  - microPublication Biology
ER  -