TY  - GEN
T1  - Exposing a novel genetic interaction between unc-33/CRMP and hmp-2/β-catenin during Caenorhabditis elegans embryogenesis
AU  - Garzanelli, John
AU  - Maiden, Stephanie
DO  - 10.17912/micropub.biology.000286
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000286/
AB  - Microtubules are critical to a number of vital cellular processes, including cell division, intracellular transport, cell movement, and cell structure. Microtubule-associated proteins (MAPs) facilitate these various microtubule functions by regulating dynamic instability, crosslinking, and trafficking, among others (Alfaro-Aco and Petry 2015). There are over 60 conserved MAPs in Caenorhabditis elegans, many with essential functions (Oegema 2006; Lacroix et al. 2014; Rose and Gonczy 2014; Quintin et al. 2016). Not surprisingly, microtubules and MAPs are required during early Caenorhabditis elegans embryogenesis when cell divisions predominate (Oegema 2006; Rose and Gonczy 2014). Temporally-controlled microtubule disruption by either drugs or transgenic constructs can bypass these early requirements and have shown that microtubules are also necessary for proper epidermal morphogenesis during mid-embryonic development (Williams-Masson et al. 1998; Quintin et al. 2016). However, it is still unclear what complement of MAPs function during this stage of development to pattern the overall microtubule network and control dynamic instability.
PY  - 2020
JO  - microPublication Biology
ER  -