TY  - GEN
T1  - The salt-inducible kinase KIN-29 regulates lifespan via the class II histone-deacetylase HDA-4
AU  - Nikooei, Tatiana
AU  - McDonagh, Aja
AU  - M. van der Linden, Alexander
DO  - 10.17912/micropub.biology.000289
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000289/
AB  - kin-29 encodes the C. elegans homolog of mammalian Salt-Inducible Kinases (SIKs). kin-29 mutants are small, have increased propensity to develop into non-reproductive dauer larvae, have reduced chemoreceptor gene expression (Lanjuin and Sengupta, 2002; van der Linden et al.., 2007), have reduced cellular ATP despite increased fat stores, and show reduced sleep (Grubbs et al., 2020). KIN-29 phosphorylates and inhibits the class II histone deacetylase 4 homolog HDA-4 to regulate gene expression in sensory neurons (van der Linden et al., 2007). The longevity phenotype of kin-29 mutants is suppressed by mutations in daf-16 (Lanjuin and Sengupta, 2002), which encodes a forkhead box protein O (FOXO) transcription factor (Kenyon et al., 1993). These results indicated that the increased lifespan of kin-29 mutants may be due to reduced insulin signaling.
PY  - 2020
JO  - microPublication Biology
ER  -